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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FIGN All Species: 18.79
Human Site: S593 Identified Species: 27.56
UniProt: Q5HY92 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5HY92 NP_060556.2 759 82146 S593 D I D M L L S S Q V N E E H S
Chimpanzee Pan troglodytes XP_001153855 674 74011 S516 R G D G E H E S S R R I K T E
Rhesus Macaque Macaca mulatta XP_001097992 759 82110 S593 D I D M L L S S Q V N E E H S
Dog Lupus familis XP_545496 695 74019 P537 Q V S E E H S P V S R M R T E
Cat Felis silvestris
Mouse Mus musculus Q9ERZ6 759 82080 S593 D I D M L L S S Q V S E E H S
Rat Rattus norvegicus Q6GX84 677 74178 S519 R G D G E H E S S R R I K T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506217 731 78137 E572 Q R G D G E H E S S R R I K T
Chicken Gallus gallus Q5ZK92 613 66247 S455 R E G E H D A S R R L K T E F
Frog Xenopus laevis Q6DDU8 655 72133 E496 Q R G E G E H E S S R R I K T
Zebra Danio Brachydanio rerio Q503S1 736 79183 S571 D V D L L L S S Q L S E E S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQN8 523 58530 S365 R S A N E N E S T L R L K N E
Honey Bee Apis mellifera XP_625184 585 66969 T427 E S S R R L K T E F L V Q L D
Nematode Worm Caenorhab. elegans O16299 594 66169 K436 H E S S R R I K T E F L V Q L
Sea Urchin Strong. purpuratus XP_783737 603 65189 R445 N D E H E S S R R I K T E F L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 V365 R V K S E L L V Q V D G V S N
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 V731 R I K N E F L V Q W S S L S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.6 99.4 72.9 N.A. 97.8 35.5 N.A. 31.6 24.8 35.7 71.2 N.A. 25.2 26.6 26.4 30.8
Protein Similarity: 100 54.9 99.4 79.1 N.A. 99.3 54.9 N.A. 47 42.2 53.4 83.7 N.A. 40.8 46.6 43.3 46.9
P-Site Identity: 100 13.3 100 6.6 N.A. 93.3 13.3 N.A. 0 6.6 0 60 N.A. 6.6 6.6 0 13.3
P-Site Similarity: 100 20 100 13.3 N.A. 100 20 N.A. 6.6 26.6 6.6 86.6 N.A. 26.6 33.3 0 40
Percent
Protein Identity: N.A. N.A. N.A. 23.9 25 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.5 N.A.
P-Site Identity: N.A. N.A. N.A. 20 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 7 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 25 7 38 7 0 7 0 0 0 0 7 0 0 0 7 % D
% Glu: 7 13 7 19 44 13 19 13 7 7 0 25 32 7 25 % E
% Phe: 0 0 0 0 0 7 0 0 0 7 7 0 0 7 7 % F
% Gly: 0 13 19 13 13 0 0 0 0 0 0 7 0 0 0 % G
% His: 7 0 0 7 7 19 13 0 0 0 0 0 0 19 0 % H
% Ile: 0 25 0 0 0 0 7 0 0 7 0 13 13 0 0 % I
% Lys: 0 0 13 0 0 0 7 7 0 0 7 7 19 13 0 % K
% Leu: 0 0 0 7 25 38 13 0 0 13 13 13 7 7 13 % L
% Met: 0 0 0 19 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 7 0 0 13 0 7 0 0 0 0 13 0 0 7 7 % N
% Pro: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 7 % P
% Gln: 19 0 0 0 0 0 0 0 38 0 0 0 7 7 0 % Q
% Arg: 38 13 0 7 13 7 0 7 13 19 38 13 7 0 0 % R
% Ser: 0 13 19 13 0 7 38 50 25 19 19 7 0 19 25 % S
% Thr: 0 0 0 0 0 0 0 7 13 0 0 7 7 19 13 % T
% Val: 0 19 0 0 0 0 0 13 7 25 0 7 13 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _